Foi divulgada oficialmente a lista das músicas que estarão presentes no novo Rock Band 2. Confira os sons que vêm por aí:

- AC/DC - Let There Be Rock
- AFI - Girl's Gone Grey
- Alanis Morissete - You Oughta Know
- Alice in Chains - Man in the Box
- Aliman Brothers - Ramblin' Man
- Avenged Sevenfold - Almost Easy
- Bad Company - Shooting Star
- Beastlie Boys - So Whatcha Want
- Beck - E-Pro
- Bikini Kill - Rebel Girl
- Billy Idol - White Wedding Pt. I
- Blondie - One Way or Another
- Bob Dylan - Tangled Up in Blue
- Bon Jovi - Livin' on a Prayer
- Cheap Trick - Hello There
- Devo - Uncontrollable Urge
- Dinossaur Jr. - Feel the Pain
- Disturbed - Down with the Sickness
- Dream Theater - Panic Attack
- Duran Duran - Hungry Like the Wolf
- Elvis Costello - Pump It Up
- Fleetwood Mac - Go Your Own Way
- Foo Fighters - Everlong
- Guns 'n Roses - Shackler's Revenge
- Interpol - PDA
- Jane's Addiction - Mountain Song
- Jethro Tull - Aqualung
- Jimmy Eat World - The Middle
- Joan Jelt - Bad Reputation
- Journey - Anyway You Want It
- Judas Priest - Painkiller
- Kansas - Carry On Wayward Son
- L7 - Pretend We're Dead
- Lacuna Coil - Our Truth
- Linkin Park - One Step Closer
- Lit - My Own Worst Enemy
- Lush - De-Luxe
- Mastodon - Colony of Birchmen
- Megadeth - Peace Sells
- Metallica - Battery
- Mighty Mighty Bosstones - Where'd You Go
- Modest Mouse - Float On
- Motorhead - Ace of Spades
- Nirvana - Drain You
- Norman Greenbaum - Spirit in the Sky
- Panic at the Disco - Nine in the Aftermoon
- Paramore - That's What You Get
- Pearl Jam - Alive
- Presidents of the USA - Lump
- Rage Against the Machine - Testify
- Ratt - Round & Round
- Red Hot Chili Peppers - Give It Away
- Rise Against - Give It All
- Rush - The Trees
- Silversun Pickups - Lazy Eye
- Smashing Pumpkins - Today
- Social Distortion - I Was Wrong
- Sonic Youth - Teenage Riot
- Soudgarden - Spoonman
- Squeeze - Cool for Cats
- Steely Dan - Bodhitsattya
- Steve Miller Band - Rock'n Me
- Survivor - Eye of the Tiger
- System of a Down - Chop Suey
- Talking Heads - Psycho Killer
- Tenacious D - Master Exploder
- Testament - Souls of Black
- The Donnas - New Kid in School
- The Go-Go's - We Got the Beat
- The Grateful Dead - Alabama Gateway
- The Guess Who - American Woman
- The Muffs - Kids in America
- The Offspring - Come Out & Play (Keep 'em Separated)
- The Replacements - Alex Chilton
- The Who - Pinball Wizard

Faixas Bônus

- Abnormality - Visions
- Anarchy Club - Get Clean
- Bang Camaro - Night Lies
- Breaking Wheel - Shoulder to the Plow
- The Libyans - Neighborhood
- The Main Drag - A Jagged Gorgeous Winter
- Speck - Conventional Lover
- The Sterms - Supreme Girl
- The Handsome Devil - Rob the Prez-O-Dent